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In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

The relatively recent discovery and characterization of human broadly neutralizing antibodies (bnAbs) against influenza virus provide valuable insights into antiviral and vaccine development. However, the factors that influence the evolution of high-affinity bnAbs remain elusive. We therefore explor...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Wu, Nicholas C., Grande, Geramie, Turner, Hannah L., Ward, Andrew B., Xie, Jia, Lerner, Richard A., Wilson, Ian A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440694/
https://ncbi.nlm.nih.gov/pubmed/28504265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15371
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