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SNP detection using peptide nucleic acid probes and conjugated polymers: Applications in neurodegenerative disease identification

A strategy employing a combination of peptide nucleic acid (PNA) probes, an optically amplifying conjugated polymer (CP), and S1 nuclease enzyme is capable of detecting SNPs in a simple, rapid, and sensitive manner. The recognition is accomplished by sequence-specific hybridization between the uncha...

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Detalhes bibliográficos
Main Authors: Gaylord, Brent S., Massie, Michelle R., Feinstein, Stuart C., Bazan, Guillermo C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544065/
https://ncbi.nlm.nih.gov/pubmed/15618399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407578101
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