Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a soluble extracellular domain of Axl that traps Gas6 protects mice against life-threatening thrombosis. Loss of a Gas6-R...

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Hlavní autoři: Angelillo-Scherrer, Anne, Burnier, Laurent, Flores, Nathalie, Savi, Pierre, DeMol, Maria, Schaeffer, Paul, Herbert, Jean-Marc, Lemke, Greg, Goff, Stephen P., Matsushima, Glenn K., Earp, H. Shelton, Vesin, Christian, Hoylaerts, Marc F., Plaisance, Stéphane, Collen, Désiré, Conway, Edward M., Wehrle-Haller, Bernhard, Carmeliet, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC544035/
https://ncbi.nlm.nih.gov/pubmed/15650770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522079
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