Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a soluble extracellular domain of Axl that traps Gas6 protects mice against life-threatening thrombosis. Loss of a Gas6-R...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Angelillo-Scherrer, Anne, Burnier, Laurent, Flores, Nathalie, Savi, Pierre, DeMol, Maria, Schaeffer, Paul, Herbert, Jean-Marc, Lemke, Greg, Goff, Stephen P., Matsushima, Glenn K., Earp, H. Shelton, Vesin, Christian, Hoylaerts, Marc F., Plaisance, Stéphane, Collen, Désiré, Conway, Edward M., Wehrle-Haller, Bernhard, Carmeliet, Peter
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2005
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544035/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15650770/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI22079
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