Alternative splicing of EZH2 pre-mRNA by SF3B3 contributes to the tumorigenic potential of renal cancer

PURPOSE: Deregulation or mutation of the EZH2 gene causes various tumors, including ccRCC. Although several splice variants of EZH2 have been identified, little is known about how EZH2 splicing is regulated or the contribution of alternative splicing to its pro-tumorigenic functions. EXPERIMENTAL DE...

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Опубликовано в: :Clin Cancer Res
Главные авторы: Chen, Ke, Xiao, Haibing, Zeng, Jin, Yu, Gan, Zhou, Hui, Huang, Chunhua, Yao, Weimin, Xiao, Wei, Hu, Junhui, Guan, Wei, Wu, Lily, Huang, Jiaoti, Huang, Qihong, Xu, Hua, Ye, Zhangqun
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440213/
https://ncbi.nlm.nih.gov/pubmed/27879367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2020
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