Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer’s disease

Precuneus (PreC) cortex is affected with amyloid plaques early in Alzheimer’s disease (AD), and this pathology may be associated with alterations in PreC synapses and cognitive impairment. We quantified the spinophilin-immunoreactive (ir) dendritic spine density and the intensity of spinophilin immu...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Mi, Zhiping, Abrahamson, Eric E., Ryu, Angela Y., Fish, Kenneth N., Sweet, Robert A., Mufson, Elliott J., Ikonomovic, Milos D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440205/
https://ncbi.nlm.nih.gov/pubmed/28259365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2017.01.022
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