Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer’s disease

Precuneus (PreC) cortex is affected with amyloid plaques early in Alzheimer’s disease (AD), and this pathology may be associated with alterations in PreC synapses and cognitive impairment. We quantified the spinophilin-immunoreactive (ir) dendritic spine density and the intensity of spinophilin immu...

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Bibliografiske detaljer
Udgivet i:Neurobiol Aging
Main Authors: Mi, Zhiping, Abrahamson, Eric E., Ryu, Angela Y., Fish, Kenneth N., Sweet, Robert A., Mufson, Elliott J., Ikonomovic, Milos D.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440205/
https://ncbi.nlm.nih.gov/pubmed/28259365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2017.01.022
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