MOZ-TIF2 Inhibits Transcription by Nuclear Receptors and p53 by Impairment of CBP Function

Chromosomal rearrangements associated with acute myeloid leukemia (AML) include fusions of the genes encoding the acetyltransferase MOZ or MORF with genes encoding the nuclear receptor coactivator TIF2, p300, or CBP. Here we show that MOZ-TIF2 acts as a dominant inhibitor of the transcriptional acti...

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Autores principales: Kindle, Karin B., Troke, Philip J. F., Collins, Hilary M., Matsuda, Sachiko, Bossi, Daniela, Bellodi, Cristian, Kalkhoven, Eric, Salomoni, Paolo, Pelicci, Pier Giuseppe, Minucci, Saverio, Heery, David M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC544007/
https://ncbi.nlm.nih.gov/pubmed/15657427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.3.988-1002.2005
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