c-Jun N-Terminal Kinase Contributes to Aberrant Retinoid Signaling in Lung Cancer Cells by Phosphorylating and Inducing Proteasomal Degradation of Retinoic Acid Receptor α

Retinoic acid (RA) is the ligand for nuclear RA receptors (RARs and RXRs) and is crucial for normal epithelial cell growth and differentiation. During malignant transformation, human bronchial epithelial cells acquire a block in retinoid signaling caused in part by a transcriptional defect in RARs....

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Détails bibliographiques
Auteurs principaux: Srinivas, Harish, Juroske, Denise M., Kalyankrishna, Shailaja, Cody, Dianna D., Price, Roger E., Xu, Xiao-Chun, Narayanan, Ramesh, Weigel, Nancy L., Kurie, Jonathan M.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC543999/
https://ncbi.nlm.nih.gov/pubmed/15657432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.3.1054-1069.2005
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