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Akt phosphorylates and suppresses the transactivation of retinoic acid receptor α

The transactivation of nuclear receptors is regulated by both ligand binding and phosphorylation. We previously showed that RARα (retinoic acid receptor α) phosphorylation by c-Jun N-terminal kinase contributes to retinoid resistance in a subset of NSCLC cells (non-small cell lung cancer cells), but...

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Detalhes bibliográficos
Main Authors: Srinivas, Harish, Xia, Dianren, Moore, Nicole L., Uray, Ivan P., Kim, Heetae, Ma, Long, Weigel, Nancy L., Brown, Powel H., Kurie, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462695/
https://ncbi.nlm.nih.gov/pubmed/16417524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051794
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