Liposomal formulation of a methotrexate lipophilic prodrug: assessment in tumor cells and mouse T-cell leukemic lymphoma

In a previous study, a formulation of methotrexate (MTX) incorporated in the lipid bilayer of 100-nm liposomes in the form of diglyceride ester (MTX-DG, lipophilic prodrug) was developed. In this study, first, the interactions of MTX-DG liposomes with various human and mouse tumor cell lines were st...

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Опубликовано в: :Int J Nanomedicine
Главные авторы: Alekseeva, Anna A, Moiseeva, Ekaterina V, Onishchenko, Natalia R, Boldyrev, Ivan A, Singin, Alexander S, Budko, Andrey P, Shprakh, Zoya S, Molotkovsky, Julian G, Vodovozova, Elena L
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2017
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439940/
https://ncbi.nlm.nih.gov/pubmed/28553111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S133034
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