Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome

Neurogenesis impairment is considered a major determinant of the intellectual disability that characterizes Down syndrome (DS), a genetic condition caused by triplication of chromosome 21. Previous evidence obtained in the Ts65Dn mouse model of DS showed that the triplicated gene APP (amyloid precur...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Stagni, Fiorenza, Raspanti, Alessandra, Giacomini, Andrea, Guidi, Sandra, Emili, Marco, Ciani, Elisabetta, Giuliani, Alessandro, Bighinati, Andrea, Calzà, Laura, Magistretti, Jacopo, Bartesaghi, Renata
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439029/
https://ncbi.nlm.nih.gov/pubmed/28359846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.03.012
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