Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome

Neurogenesis impairment starting from early developmental stages is a key determinant of intellectual disability in Down syndrome (DS). Previous evidence provided a causal relationship between neurogenesis impairment and malfunctioning of the mitogenic Sonic Hedgehog (Shh) pathway. In particular, ex...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Giacomini, Andrea, Stagni, Fiorenza, Trazzi, Stefania, Guidi, Sandra, Emili, Marco, Brigham, Elizabeth, Ciani, Elisabetta, Bartesaghi, Renata
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768084/
https://ncbi.nlm.nih.gov/pubmed/26254735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.08.001
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