Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Artocarpin has been shown to exhibit cytotoxic effects on different cancer cells, including non-small cell lung carcinoma (NSCLC, A549). However, the underlying mechanisms remain unclear. Here, we explore both p53-dependent and independent apoptosis pathways in artocarpin-treated NSCLC cells. Our re...

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Udgivet i:Oncotarget
Main Authors: Tsai, Ming-Horng, Liu, Ju-Fang, Chiang, Yao-Chang, Chu-Sung Hu, Stephen, Hsu, Lee-Fen, Lin, Yu-Ching, Lin, Zih-Chan, Lee, Hui-Chun, Chen, Mei-Chuan, Huang, Chieh-Liang, Lee, Chiang-Wen
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
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Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438654/
https://ncbi.nlm.nih.gov/pubmed/28423703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16058
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