HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model

T lymphocytes against tumor-specific mutated neoantigens can induce tumor regression. Also, the size of the immunogenic cancer mutanome is supposed to correlate with the clinical efficacy of checkpoint inhibition. Herein, we studied the susceptibility of tumor cell lines from lymph node metastases o...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Schrörs, Barbara, Lübcke, Silke, Lennerz, Volker, Fatho, Martina, Bicker, Anne, Wölfel, Catherine, Derigs, Patrick, Hankeln, Thomas, Schadendorf, Dirk, Paschen, Annette, Wölfel, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438652/
https://ncbi.nlm.nih.gov/pubmed/28423700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16048
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares