HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model

T lymphocytes against tumor-specific mutated neoantigens can induce tumor regression. Also, the size of the immunogenic cancer mutanome is supposed to correlate with the clinical efficacy of checkpoint inhibition. Herein, we studied the susceptibility of tumor cell lines from lymph node metastases o...

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Vydáno v:Oncotarget
Hlavní autoři: Schrörs, Barbara, Lübcke, Silke, Lennerz, Volker, Fatho, Martina, Bicker, Anne, Wölfel, Catherine, Derigs, Patrick, Hankeln, Thomas, Schadendorf, Dirk, Paschen, Annette, Wölfel, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438652/
https://ncbi.nlm.nih.gov/pubmed/28423700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16048
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