Widespread position-specific conservation of synonymous rare codons within coding sequences

Synonymous rare codons are considered to be sub-optimal for gene expression because they are translated more slowly than common codons. Yet surprisingly, many protein coding sequences include large clusters of synonymous rare codons. Rare codons at the 5’ terminus of coding sequences have been shown...

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Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Chaney, Julie L., Steele, Aaron, Carmichael, Rory, Rodriguez, Anabel, Specht, Alicia T., Ngo, Kim, Li, Jun, Emrich, Scott, Clark, Patricia L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438181/
https://ncbi.nlm.nih.gov/pubmed/28475588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005531
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