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Widespread position-specific conservation of synonymous rare codons within coding sequences

Synonymous rare codons are considered to be sub-optimal for gene expression because they are translated more slowly than common codons. Yet surprisingly, many protein coding sequences include large clusters of synonymous rare codons. Rare codons at the 5’ terminus of coding sequences have been shown...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Chaney, Julie L., Steele, Aaron, Carmichael, Rory, Rodriguez, Anabel, Specht, Alicia T., Ngo, Kim, Li, Jun, Emrich, Scott, Clark, Patricia L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438181/
https://ncbi.nlm.nih.gov/pubmed/28475588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005531
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