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Expanding Anfinsen’s Principle: Contributions of Synonymous Codon Selection to Rational Protein Design
[Image: see text] Anfinsen’s principle asserts that all information required to specify the structure of a protein is encoded in its amino acid sequence. However, during protein synthesis by the ribosome, the N-terminus of the nascent chain can begin to fold before the C-terminus is available. We te...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3959793/ https://ncbi.nlm.nih.gov/pubmed/24392935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja411302m |
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