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Synonymous codon substitutions perturb cotranslational protein folding in vivo and impair cell fitness
In the cell, proteins are synthesized from N to C terminus and begin to fold during translation. Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as a function of synonymous codon usage. However, synonymous codon substitutions can affect many distinct cellular...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7035613/ https://ncbi.nlm.nih.gov/pubmed/32015130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907126117 |
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