Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe a cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with the L-type calcium channel. Knockdown of Myoscape in cardiomyocytes decreases calcium transients associated with smaller Ca(2+...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Eden, Matthias, Meder, Benjamin, Völkers, Mirko, Poomvanicha, Montatip, Domes, Katrin, Branchereau, M., Marck, P., Will, Rainer, Bernt, Alexander, Rangrez, Ashraf, Busch, Matthias, Hrabě de Angelis, Martin, Heymes, Christophe, Rottbauer, Wolfgang, Most, Patrick, Hofmann, Franz, Frey, Norbert
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438100/
https://ncbi.nlm.nih.gov/pubmed/27122098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11317
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