Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex

Deficits in cognitive flexibility are prominent in stress-related psychiatric disorders, including depression. Ketamine has rapid antidepressant efficacy, but it is unknown if ketamine improves cognitive symptoms. In rats, 2 weeks chronic intermittent cold (CIC) stress impairs reversal learning, a f...

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Publicat a:Neuropsychopharmacology
Autors principals: Patton, Michael S, Lodge, Daniel J, Morilak, David A, Girotti, Milena
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437880/
https://ncbi.nlm.nih.gov/pubmed/27748739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.236
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