Acquisition of negative complement regulators by the saprophyte Leptospira biflexa expressing LigA or LigB confers enhanced survival in human serum

Leptospiral immunoglobulin-like (Lig) proteins are surface exposed molecules present in pathogenic but not in saprophytic Leptospira species. We have previously shown that Lig proteins interact with the soluble complement regulators Factor H (FH), FH like-1 (FHL-1), FH related-1 (FHR-1) and C4b Bind...

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Udgivet i:Immunol Lett
Main Authors: Castiblanco-Valencia, Mónica M., Fraga, Tatiana R., Breda, Leandro C.D., Vasconcellos, Sílvio A., Figueira, Cláudio P., Picardeau, Mathieu, Wunder, Elsio, Ko, Albert I., Barbosa, Angela S., Isaac, Lourdes
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437552/
https://ncbi.nlm.nih.gov/pubmed/26976804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imlet.2016.03.005
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