Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

The metalloid tellurite is highly toxic to microorganisms. Several mechanisms of action have been proposed, including thiol depletion and generation of hydrogen peroxide and superoxide, but none of them can fully explain its toxicity. Here we use a combination of directed evolution and chemical and...

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Pubblicato in:Nat Commun
Autori principali: Morales, Eduardo H., Pinto, Camilo A., Luraschi, Roberto, Muñoz-Villagrán, Claudia M., Cornejo, Fabián A., Simpkins, Scott W., Nelson, Justin, Arenas, Felipe A., Piotrowski, Jeff S., Myers, Chad L., Mori, Hirotada, Vásquez, Claudio C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437285/
https://ncbi.nlm.nih.gov/pubmed/28492282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15320
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