Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

The metalloid tellurite is highly toxic to microorganisms. Several mechanisms of action have been proposed, including thiol depletion and generation of hydrogen peroxide and superoxide, but none of them can fully explain its toxicity. Here we use a combination of directed evolution and chemical and...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Morales, Eduardo H., Pinto, Camilo A., Luraschi, Roberto, Muñoz-Villagrán, Claudia M., Cornejo, Fabián A., Simpkins, Scott W., Nelson, Justin, Arenas, Felipe A., Piotrowski, Jeff S., Myers, Chad L., Mori, Hirotada, Vásquez, Claudio C.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437285/
https://ncbi.nlm.nih.gov/pubmed/28492282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15320
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