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Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite
The metalloid tellurite is highly toxic to microorganisms. Several mechanisms of action have been proposed, including thiol depletion and generation of hydrogen peroxide and superoxide, but none of them can fully explain its toxicity. Here we use a combination of directed evolution and chemical and...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5437285/ https://ncbi.nlm.nih.gov/pubmed/28492282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15320 |
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