Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

The metalloid tellurite is highly toxic to microorganisms. Several mechanisms of action have been proposed, including thiol depletion and generation of hydrogen peroxide and superoxide, but none of them can fully explain its toxicity. Here we use a combination of directed evolution and chemical and...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Morales, Eduardo H., Pinto, Camilo A., Luraschi, Roberto, Muñoz-Villagrán, Claudia M., Cornejo, Fabián A., Simpkins, Scott W., Nelson, Justin, Arenas, Felipe A., Piotrowski, Jeff S., Myers, Chad L., Mori, Hirotada, Vásquez, Claudio C.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437285/
https://ncbi.nlm.nih.gov/pubmed/28492282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15320
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы