Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one inflammasome constituent, but little is known about its cellular handling. Here we show a mechanism for N...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Bednash, Joseph S., Weathington, Nathaniel, Londino, James, Rojas, Mauricio, Gulick, Dexter L., Fort, Robert, Han, SeungHye, McKelvey, Alison C., Chen, Bill B., Mallampalli, Rama K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437278/
https://ncbi.nlm.nih.gov/pubmed/28492230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15203
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