Post-translational modification of the interferon-gamma receptor alters its stability and signaling

The IFN gamma receptor 1 (IFNGR1) binds IFN-γ and activates gene transcription path ways crucial for controlling bacterial and viral infections. Although decreases in IFNGR1 surface levels have been demonstrated to inhibit IFN-γ signaling, little is known regarding the molecular mechanisms controlli...

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Publicat a:Biochem J
Autors principals: Londino, James D., Gulick, Dexter L., Lear, Travis B., Suber, Tomeka L., Weathington, Nathaniel M., Masa, Luke S., Chen, Bill B., Mallampalli, Rama K.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967388/
https://ncbi.nlm.nih.gov/pubmed/28883123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170548
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