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Galectin-3 interacts with the cell-surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells

The galactoside-binding protein galectin-3 is increasingly recognized as an important player in cancer development, progression, and metastasis via its interactions with various galactoside-terminated glycans. We have shown previously that circulating galectin-3, which is increased up to 30-fold in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Colomb, Florent, Wang, Weikun, Simpson, Deborah, Zafar, Mudaser, Beynon, Robert, Rhodes, Jonathan M., Yu, Lu-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437243/
https://ncbi.nlm.nih.gov/pubmed/28364041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.783431
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