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Sialylation of β1 Integrins Blocks Cell Adhesion to Galectin-3 and Protects Cells against Galectin-3-induced Apoptosis

In previous studies, we determined that β1 integrins from human colon tumors have elevated levels of α2-6 sialylation, a modification added by β-galactosamide α-2,6-sialyltranferase I (ST6Gal-I). Intriguingly, the β1 integrin is thought to be a ligand for galectin-3 (gal-3), a tumor-associated lecti...

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Detalhes bibliográficos
Main Authors: Zhuo, Ya, Chammas, Roger, Bellis, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494929/
https://ncbi.nlm.nih.gov/pubmed/18676377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M8000015200
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