Myocardial tissue deformation is reduced in subjects with coronary microvascular dysfunction but not rescued by treatment with ranolazine

BACKGROUND: Patients with coronary microvascular dysfunction (CMD) often have diastolic dysfunction, representing an important therapeutic target. Ranolazine—a late sodium current inhibitor—improves diastolic function in animal models and subjects with obstructive coronary artery disease (CAD). HYPO...

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Veröffentlicht in:Clin Cardiol
Hauptverfasser: Nelson, Michael D., Sharif, Behzad, Shaw, Jaime L., Cook‐Wiens, Galen, Wei, Janet, Shufelt, Chrisandra, Mehta, Puja K., Thomson, Louise E. J., Berman, Daniel S., Thompson, Richard B., Handberg, Eileen M., Pepine, Carl J., Li, Debiao, Bairey Merz, C. Noel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley Periodicals, Inc. 2016
Schlagworte:
Clinical Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436931/
https://ncbi.nlm.nih.gov/pubmed/28004395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/clc.22660
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