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Complex transcriptional modulation with orthogonal and inducible dCas9 regulators
The ability to dynamically manipulate the transcriptome is important for studying how gene networks direct cellular functions and how network perturbations cause disease. Nuclease-dead CRISPR–dCas9 transcriptional regulators, while offering an approach for controlling individual gene expression, rem...
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| Pubblicato in: | Nat Methods |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5436902/ https://ncbi.nlm.nih.gov/pubmed/27776111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4042 |
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