Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase

To study the impact of epigenetic changes on biological functions, the ability to manipulate the epigenetic status of certain genomic regions artificially could be an indispensable technology. “Epigenome editing” techniques have gradually emerged that apply TALE or CRISPR/Cas9 technologies with vari...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Yamazaki, Taiga, Hatano, Yu, Handa, Tetsuya, Kato, Sakiko, Hoida, Kensuke, Yamamura, Rui, Fukuyama, Takashi, Uematsu, Takayuki, Kobayashi, Noritada, Kimura, Hiroshi, Yamagata, Kazuo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436701/
https://ncbi.nlm.nih.gov/pubmed/28542388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177764
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