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Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase

To study the impact of epigenetic changes on biological functions, the ability to manipulate the epigenetic status of certain genomic regions artificially could be an indispensable technology. “Epigenome editing” techniques have gradually emerged that apply TALE or CRISPR/Cas9 technologies with vari...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yamazaki, Taiga, Hatano, Yu, Handa, Tetsuya, Kato, Sakiko, Hoida, Kensuke, Yamamura, Rui, Fukuyama, Takashi, Uematsu, Takayuki, Kobayashi, Noritada, Kimura, Hiroshi, Yamagata, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436701/
https://ncbi.nlm.nih.gov/pubmed/28542388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177764
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