Splicing factor SF3B1(K700E) mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

More than 60% of myeloid dysplasia syndrome (MDS) contains mutations in genes encoding for splicing factors such as SF3B1, U2AF, SRSF2 and ZRSR2. Mutations in SF3B1 are associated with 80% cases of refractory anemia with ring sideroblast (RARS), a subtype of MDS. SF3B1(K700E) is the most frequently...

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Vydáno v:PLoS One
Hlavní autoři: Jin, Shuiling, Su, Hairui, Tran, Ngoc-Tung, Song, Jing, Lu, Sydney S., Li, Ying, Huang, Suming, Abdel-Wahab, Omar, Liu, Yanyan, Zhao, Xinyang
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436638/
https://ncbi.nlm.nih.gov/pubmed/28545085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175523
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