Foxp3(+) regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

Foxp3(+) regulatory T cells (Treg cells) modulate the immune system and maintain self-tolerance, but whether they affect haematopoiesis or haematopoietic stem cell (HSC)-mediated reconstitution after transplantation is unclear. Here we show that B-cell lymphopoiesis is impaired in Treg-depleted mice...

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Pubblicato in:Nat Commun
Autori principali: Pierini, Antonio, Nishikii, Hidekazu, Baker, Jeanette, Kimura, Takaharu, Kwon, Hye-Sook, Pan, Yuqiong, Chen, Yan, Alvarez, Maite, Strober, William, Velardi, Andrea, Shizuru, Judith A., Wu, Joy Y., Chiba, Shigeru, Negrin, Robert S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436085/
https://ncbi.nlm.nih.gov/pubmed/28485401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15068
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