Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells

It is generally accepted that intracellular oxidative stress induced by proteasome inhibitors is a byproduct of endoplasmic reticulum (ER) stress. Here, we report a mechanism underlying the ability of proteasome inhibitors bortezomib (BTZ) and carfilzomib (CFZ) to directly induce oxidative and ER st...

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Bibliografiske detaljer
Udgivet i:Leukemia
Main Authors: Fink, Emily E., Mannava, Sudha, Bagati, Archis, Bianchi-Smiraglia, Anna, Nair, Jayakumar R., Moparthy, Kalyana, Lipchick, Brittany C., Drokov, Mikhail, Utley, Adam, Ross, Jason, Mendeleeva, Larisa P., Savchenko, Valery G., Lee, Kelvin P., Nikiforov, Mikhail A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436048/
https://ncbi.nlm.nih.gov/pubmed/26205085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.190
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