Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system

Genome editing research of human ES/iPS cells has been accelerated by clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9) and transcription activator-like effector nucleases (TALEN) technologies. However, the efficiency of biallelic genetic engineering in tran...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Takayama, Kazuo, Igai, Keisuke, Hagihara, Yasuko, Hashimoto, Rina, Hanawa, Morifumi, Sakuma, Tetsushi, Tachibana, Masashi, Sakurai, Fuminori, Yamamoto, Takashi, Mizuguchi, Hiroyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435997/
https://ncbi.nlm.nih.gov/pubmed/28334759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx130
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