The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine

The excision of 8-oxoguanine (oxoG) by the human 8-oxoguanine DNA glycosylase 1 (hOGG1) base-excision repair enzyme was studied by using the QM/MM (M06-2X/6-31G(d,p):OPLS2005) calculation method and nuclear magnetic resonance (NMR) spectroscopy. The calculated glycosylase reaction included excision...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Šebera, Jakub, Hattori, Yoshikazu, Sato, Daichi, Řeha, David, Nencka, Radim, Kohno, Takashi, Kojima, Chojiro, Tanaka, Yoshiyuki, Sychrovský, Vladimír
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435939/
https://ncbi.nlm.nih.gov/pubmed/28334993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx157
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