Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells

Vascular calcification resulting from hyperphosphatemia is a major determinant of mortality in chronic kidney disease (CKD). Vascular calcification is driven by aldosterone-sensitive osteogenic transformation of vascular smooth muscle cells (VSMCs). We show that even in absence of exogenous aldoster...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Alesutan, Ioana, Voelkl, Jakob, Feger, Martina, Kratschmar, Denise V., Castor, Tatsiana, Mia, Sobuj, Sacherer, Michael, Viereck, Robert, Borst, Oliver, Leibrock, Christina, Gawaz, Meinrad, Kuro-o, Makoto, Pilz, Stefan, Tomaschitz, Andreas, Odermatt, Alex, Pieske, Burkert, Wagner, Carsten A., Lang, Florian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435689/
https://ncbi.nlm.nih.gov/pubmed/28515448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01882-2
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