Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM

The natural small molecule compound: 2,3,5,6-tetramethylpyrazine (TMP), is a major component of the Chinese medicine Chuanxiong, which has wide clinical applications in dilating blood vessels, inhibiting platelet aggregation and treating thrombosis. Recent work suggests that TMP is also an antitumou...

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Vydáno v:Biosci Rep
Hlavní autoři: Lan, Linhua, Guo, Miaomiao, Ai, Yong, Chen, Fuhong, Zhang, Ya, Xia, Lei, Huang, Dawei, Niu, Lili, Zheng, Ying, Suzuki, Carolyn K., Zhang, Yihua, Liu, Yongzhang, Lu, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434891/
https://ncbi.nlm.nih.gov/pubmed/28465355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20170319
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