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Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags

Small ubiquitin like modifier (SUMO) proteins are known to regulate many important cellular processes such as transcription and apoptosis. Recently, hybrid SUMO-ubiquitin chains containing SUMO-2 linked to Lys63-di-ubiquitin were found to play a major role in DNA repair. Despite some progress in und...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Bondalapati, Somasekhar, Eid, Emad, Mali, Sachitanand M., Wolberger, Cynthia, Brik, Ashraf
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434752/
https://ncbi.nlm.nih.gov/pubmed/28580118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00488e
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