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Connexin–purinergic signaling in enteric glia mediates the prolonged effect of morphine on constipation
Morphine is one of the most widely used drugs for the treatment of pain. However, side effects, including persistent constipation and antinociceptive tolerance, limit its clinical efficacy. Prolonged morphine treatment results in a “leaky” gut, predisposing to colonic inflammation that is facilitate...
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| Publicado no: | FASEB J |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5434649/ https://ncbi.nlm.nih.gov/pubmed/28280004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601068R |
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