Analysis of Mutations in Fibroblast Growth Factor (FGF) and a Pathogenic Mutation in FGF Receptor (FGFR) Provides Direct Evidence for the Symmetric Two-End Model for FGFR Dimerization

Two competing models for fibroblast growth factor (FGF) receptor (FGFR) dimerization have recently emerged based on ternary FGF-FGFR-heparin crystal structures. In the symmetric two-end model, heparin promotes dimerization of two FGF-FGFR complexes by stabilizing bivalent interactions of the ligand...

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Bibliografiska uppgifter

I publikationen:	Mol Cell Biol
Huvudupphov:	Ibrahimi, Omar A., Yeh, Brian K., Eliseenkova, Anna V., Zhang, Fuming, Olsen, Shaun K., Igarashi, Makoto, Aaronson, Stuart A., Linhardt, Robert J., Mohammadi, Moosa
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Taylor & Francis 2005
Ämnen:	Signal Transduction
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC543411/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15632068/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.25.2.671-684.2005
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