Analysis of Mutations in Fibroblast Growth Factor (FGF) and a Pathogenic Mutation in FGF Receptor (FGFR) Provides Direct Evidence for the Symmetric Two-End Model for FGFR Dimerization

Two competing models for fibroblast growth factor (FGF) receptor (FGFR) dimerization have recently emerged based on ternary FGF-FGFR-heparin crystal structures. In the symmetric two-end model, heparin promotes dimerization of two FGF-FGFR complexes by stabilizing bivalent interactions of the ligand...

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Main Authors: Ibrahimi, Omar A., Yeh, Brian K., Eliseenkova, Anna V., Zhang, Fuming, Olsen, Shaun K., Igarashi, Makoto, Aaronson, Stuart A., Linhardt, Robert J., Mohammadi, Moosa
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC543411/
https://ncbi.nlm.nih.gov/pubmed/15632068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.2.671-684.2005
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