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Crumbs binding to the Par-6 CRIB-PDZ module is regulated by Cdc42
Par-6 is a scaffold protein that organizes other proteins into a complex required to initiate and maintain cell polarity. Cdc42-GTP binds the CRIB module of Par-6 and alters the binding affinity of the adjoining PDZ domain. Allosteric regulation of the Par-6 PDZ domain was first demonstrated using a...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5433836/ https://ncbi.nlm.nih.gov/pubmed/26894406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01342 |
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