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Allosteric activation of the Par-6 PDZ via a partial unfolding transition
Proteins exist in a delicate balance between the native and unfolded states, where thermodynamic stability may be sacrificed to attain the flexibility required for efficient catalysis, binding or allosteric control. Par-6 regulates the Par polarity complex by transmitting a GTPase signal through the...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3736553/ https://ncbi.nlm.nih.gov/pubmed/23705660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400092a |
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