HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses

This study focused on HLA-A24 and comprehensively analyzed the ligandome of colon and lung cancer cells without the use of MHC-binding in silico prediction algorithms. Affinity purification using the antibody specific to HLA-A24 followed by LC–MS/MS sequencing was used to detect peptides, which harb...

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Veröffentlicht in:Oncoimmunology
Hauptverfasser: Kochin, Vitaly, Kanaseki, Takayuki, Tokita, Serina, Miyamoto, Sho, Shionoya, Yosuke, Kikuchi, Yasuhiro, Morooka, Daichi, Hirohashi, Yoshihiko, Tsukahara, Tomohide, Watanabe, Kazue, Toji, Shingo, Kokai, Yasuo, Sato, Noriyuki, Torigoe, Toshihiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433517/
https://ncbi.nlm.nih.gov/pubmed/28533942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1293214
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