Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition

Cytotoxic T-lymphocytes (CTLs) lyse target cells after recognizing the complexes of peptides and MHC class I molecules (pMHC I) on cell surfaces. Tapasin is an essential component of the peptide-loading complex (PLC) and its absence influences the surface repertoire of MHC class I peptides. In the p...

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Publicat a:Oncoimmunology
Autors principals: Shionoya, Yosuke, Kanaseki, Takayuki, Miyamoto, Sho, Tokita, Serina, Hongo, Ayumi, Kikuchi, Yasuhiro, Kochin, Vitaly, Watanabe, Kazue, Horibe, Ryota, Saijo, Hiroshi, Tsukahara, Tomohide, Hirohashi, Yoshihiko, Takahashi, Hiroki, Sato, Noriyuki, Torigoe, Toshihiko
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2017
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353923/
https://ncbi.nlm.nih.gov/pubmed/28344889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1274476
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