Autoinhibition of a neuronal kinesin UNC-104/KIF1A regulates the size and density of synapses

Kinesin motor proteins transport intracellular cargos throughout cells by hydrolyzing ATP and moving along microtubule tracks. Intramolecular autoinhibitory interactions have been shown for several kinesins in vitro, however, the physiological significance of autoinhibition remains poorly understood...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Niwa, Shinsuke, Lipton, David M., Morikawa, Manatsu, Zhao, Charles, Hirokawa, Nobutaka, Lu, Hang, Shen, Kang
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432123/
https://ncbi.nlm.nih.gov/pubmed/27524618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.043
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