DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion

INTRODUCTION: The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways. Since deoxyribonucleic acid (DNA) methylation is a potent repressor of gene expressio...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Pharmgenomics Pers Med
Главные авторы: Chidambaran, Vidya, Zhang, Xue, Martin, Lisa J, Ding, Lili, Weirauch, Matthew T, Geisler, Kristie, Stubbeman, Bobbie L, Sadhasivam, Senthilkumar, Ji, Hong
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2017
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432115/
https://ncbi.nlm.nih.gov/pubmed/28533693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S132691
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы