DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion

INTRODUCTION: The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways. Since deoxyribonucleic acid (DNA) methylation is a potent repressor of gene expressio...

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Detalhes bibliográficos
Publicado no:Pharmgenomics Pers Med
Main Authors: Chidambaran, Vidya, Zhang, Xue, Martin, Lisa J, Ding, Lili, Weirauch, Matthew T, Geisler, Kristie, Stubbeman, Bobbie L, Sadhasivam, Senthilkumar, Ji, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432115/
https://ncbi.nlm.nih.gov/pubmed/28533693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S132691
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